因美诺(上海)生物科技有限公司

Human MCP-1

Catalog# Quantity Availability PH025-005NG 0.5ng In Stock

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  • Product Summary

    The NPgPro™series is a type of ultra-low quantity protein specifically developed by ImmunoChem for immunoassay. We have optimized and developed freeze-dried formulations for different proteins. To ensure the consistency of activity and quantity of all products, we conducted rigorous validation experiments on each protein.


    hMCP-1-1


    Reconstitution

    Reconstitute the lyophilized protein in distilled water to 0.25-0.50ng/mL. Swirl or mix gently and allow the contents to sit for 15 minutes to ensure complete reconstitution, remember not to stir vigorously. Make any further usage of the reconstituted protein in buffered solution with FBS or tissue culture grade BSA.


    Typical Standard Curve



    hMCP-1-2


    Target information

    Chemokine (CC-motif) ligand 2 (CCL2), also known as MCP-1 (Monocyte chemoattractant protein-1), belongs to the CC chemokine family. As a pivotal human CC chemokine, CCL2 attracts monocytes and is encoded by a gene situated on chromosome 17q11.2-q21.1, comprising 3 exons and 2 introns. The amino terminal domain of CCL2 is indispensable for its binding capabilities. Additionally, CCL2 binds to chemokine receptors CCR2 and CCR4.

     

    CCL2 represents a superfamily of secreted proteins that play a crucial role in immunoregulatory and inflammatory processes. It aids in leukocyte recruitment, thereby contributing to protective immune responses during infections. CCL2 also modulates the activity of various signaling pathways, such as NF-κB, AKT, and ERK, which influence the development and progression of diseases, especially cancer. Given its potential involvement in various pathological conditions, numerous studies suggest that CCL2 could serve as a diagnostic tool for assessing inflammation levels in numerous diseases.



    hMCP-1-3

  • 1、hMCP-1 蛋白资料.pdf